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Fig. 7. COUP-TFII regulates migration into the intermediate zone of the neocortex. (A) Summary of the type of experiments performed on E13.5 mouse brain slices. The respective vectors are depicted to the left of each part of the diagram. (B) The average values of the GFP/GFP_tot ratio (black column) and the COUP-TFII-GFP/GFP_tot ratio (white column) in the cortex of all of the injected slices. Bars indicate standard errors of the mean. In the COUP-TFII injected side, 60±4% of the injected cells migrate into the cortex, versus 25±5% of the GFP-positive cells in the control side. Examples of control (C) and COUP-TFII mis-expressing (D) brain slices in which the vectors have been injected into the Str. (C) Arrows indicate GFP-positive cells in the MZ, whereas arrowheads indicate the IZ migratory stream. (D) Arrowheads indicate a higher amount of GFP-positive migrating cells in the IZ of the neocortex, whereas no cells are seen in the MZ (asterisk). Dotted line shows the putative boundary between neocortex and striatum. All the cells external to the dotted line have been counted as cells located in the cortex. IZ, intermediate zone; MZ, marginal zone; Str, striatum.

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