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Fig. 4. SFRP2 expression in the pallio-subpallial boundary between the dorsal (CTX) and ventral (GE) telencephalon of mice harboring mutations in the distinct DNA-binding domains of Pax6. Micrographs depict in situ-hybridization for SFRP2 mRNA in coronal sections of the telencephalon of WT and mutant littermates as indicated in the panel at embryonic day (E) 14. Note that SFRP2 expression is highest at the boundary between CTX and GE in WT mice (A,B,C,D; arrowhead in A), and Pax6(5a)–/– (B'), while its expression is lost at this position in the Pax6 mutation with a large deletion in the PD Pax6^Aey18–/– (A'), the mutation with the defect HD Pax6^4Neu–/– (C') and the functional null allele Pax6^Sey–/– (D'). Thus, both, DNA binding of the PD and the HD of Pax6 are required for SFRP2 expression at the pallial-subpallial boundary. CTX, cortex; GE, ganglionic eminence. Scale bar: 100 µm.

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