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Fig. 7. Pancreatic expression of HES1 in Gdf11-deficient mice. (A-C) Expression of HES1 (black nuclei) in Gdf11+/+, Gdf11+/- and Gdf11-/- mice at E17.5. (D) Quantification of HES1+ nuclei per mm2 tissue. The difference in numbers of HES1+ nuclei in Gdf11+/+, Gdf11+/- and Gdf11-/- mice is not significant (NS). (E,F) Gdf11 expression (rust brown) detected by in-situ hybridization in Hes1+/+ and Hes1–/– pancreata at E15.5.





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