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Fig. 4. The loss of xKaiso induces an apoptotic response in
Xenopus embryos. Wild-type (A-C) and 5 ng KMO-injected (D-F)
Xenopus embryos were assayed by TUNEL for the appearance of apoptotic
cells. TUNEL-positive cells were not detectable in normal late blastula (A)
and gastrula (B) embryos. Small numbers of apoptotic cells (arrowhead)
appeared in 1-2% of wild-type embryos at late neurula stage (C).
TUNEL-positive cells were detected in 11% and 15% of KMO-injected embryos at
late blastula (D) and gastrula stages (E), respectively. More than 90% of
KMO-injected embryos exhibited a general pattern of apoptosis at a stage
corresponding to late neurula of normally developing embryos (F).
Abbreviations: bp, blastopore; ant, anterior; post, posterior.
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