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Fig. 6. Depletion of xKaiso relieves transcriptional silence but can be rescued by overexpression of human kaiso mRNA. (A) Two array experiment comparisons were performed: WT8 versus KMO8 and WT8 versus KMO8^rescue. The x-axis shows 57 genes that were differentially expressed over a minimum 1.5-fold threshold, and the y-axis shows the fold expression changes. Genes that are elevated in KMO8 or KMO8^rescue relative to wild-type expression are shown in blue, and downregulated genes in red. (B) A representative array region showing the expression changes of five genes [Histone H1 (H1), Geminin H (GemH), cyclin A1 (CycA1), cyclin B2 (CycB2) and MEK1 (MEK1)], which are also indicated on the graph of genes shown in A. H1 expression was not rescued in KMO8^rescue embryos, whereas CycB2 is, and GemH, MEK1 and CycA1 have reduced expression levels.

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