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Fig. 3. tfr1a is the defective gene in cia. (A) (left) Radiation hybrid map of zebrafish LG 2 showing placement of tfr1a; (middle) map of human chromosome 3; (right) map of zebrafish LG24 showing the RH map position of tfr1b. Syntenic ESTs are shown, with corresponding human orthologs annotated as follows: (1) TF, (2) EIF4G1, (3) ATP1B3, (4) AHSG, (5) AP2M1, (6) LOC51714, (7) EPHB1, (8) CHST2, (9) TFRC, (10) AXUD1, (11) ORCTL3, (12) HYA22, (13) NP25, (14) FLJ11342, (15) EIF5A2. (B) Amino acid alignment of zebrafish tfr1a, tfr1b, and tfr2; dark shading indicates identical residues, asterisks mark the location of the cia^hp327, cia^hs019, cia^iu089 and cia^tu25f mutations. (C) A phylogenetic tree of the Tfr amino acid sequences reveal divergence between teleost and tetrapod Tfr1 family members, and conservation between known vertebrate Tfr2 proteins. The MegAlign application in DNAStar software was used for alignment and construction of the phylogenetic tree.

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