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First published online January 16, 2004

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Regulating heart differentiation

A major question regarding vertebrate heart development is how transcription factors broadly expressed in the embryo regulate the tightly restricted expression patterns of genes involved in cardiac muscle differentiation. Latinki and co-workers (p. 669) address this by examining how transcription factors interact to regulate the pan-myocardial expression of the Xenopus gene myosin light chain 2 (XMLC2), a sensitive marker for the onset of cardiac muscle differentiation. They show that XMLC2 has a remarkably small 82 bp core promoter containing several transcription factor-binding sites: two GATA-binding sites and a low-affinity serum response factor (SRF)-binding site overlapping a YY1-binding site. Although GATA4, SRF and YY1 are synthesised broadly in the developing embryo, it is their overlapping expression in the heart that apparently provides cardiac-specific expression of XMCL2. The XMCL2 promoter also drives pan-myocardial expression of a reporter gene in mice and the authors go on to consider the evolution of the mechanisms that drive XMCL2 expression.

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Related articles in Development:

Transcriptional regulation of the cardiac-specific MLC2 gene during Xenopus embryonic development

Branko V. Latinkic, Brian Cooper, Stuart Smith, Surendra Kotecha, Norma Towers, Duncan Sparrow, and Timothy J. Mohun
Development 2004 131: 669-679. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?