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Fig. 3. Lim1 expression in MIS signaling mutant mice. (A-D) Lateral view
of the testicular region in wild-type (A),
Misr2/ (B),
Mis/ (C) and
Wnt7a/ (D) male embryos at E15.75.
Fragmentation of Lim1tlz expression in the Müllerian
duct is observed in wild-type embryos (arrows in A), which is suppressed in
MIS signaling-deficient mutants (B-D). (E-J) Ventral view of the urogenital
system in wild-type (E,G,I) and MT-hMIStg/+ transgenic
(F,H,J) female embryos. (K,L) Ventral view of the testicular region in
wild-type (K) and MT-hMIStg/+ transgenic (L) male embryos.
Note that fragmentation of Lim1tlz expression in the
Müllerian duct is enhanced in MIS transgenic males. k, kidney
(metanephros); md, Müllerian duct; od, oviduct; ut, uterus; wd, Wolffian
duct. Scale bars: 250 µm in A-D; 500 µm in E-L.