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Fig. 4. Absence of the female reproductive tract in Lim1–/– female neonates. (A,B) Newborns of wild-type (A) and Lim1–/– (B). (C,D) Gross view of the female reproductive system from wild-type (C) and Lim1–/– (D) newborns. (E,F) High magnification of the anterior gonadal region in C and D, respectively. Note that Lim1–/– XX newborns have normal ovaries (ov). (G,H) Longitudinal sections of the urogenital system from wild-type (G) and Lim1–/– (H) female newborns. Note that neither epithelium nor mesenchyme of the female reproductive tract is found in Lim1–/– XX mice (asterisk in H). b, bladder; cv, cervix; ge, genitalia; mg, midgut; od, oviduct; ov, ovary; pb, pubic bone; r, rectum; ut, uterus; vg, vagina. Scale bars: 5 mm in A,B; 500 µm in C-H.





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