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Fig. 7. Lim1 expression in mouse mutants with Müllerian duct abnormalities. (A-D) Ventral view of the right urogenital system in wild-type (A), Wnt4^–/–(B), Pax2^–/–(C) and Wnt7a^–/–(D) embryos at E12.5. (E,F) Ventral view of the anterior urogenital system in Wnt4^+/– (E) and Wnt4^–/–(F) embryos at E11.5. Arrows in F indicate Lim1^tlz expressing presumptive Müllerian duct precursor cells. (G,H) Lateral view with high magnification. Note that Lim1^tlz-positive Müllerian duct precursor cells do not show funnel-shaped invagination (arrow in H). Broken lines indicate the gonad. k, kidney (metanephros); m, mesonephros; md, Müllerian duct; wd, Wolffian duct. Scale bars: 250 µm in A-F; 100 µm in G,H.

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