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Fig. 4. Six1 expression pattern during inner ear development detected by
in situ hybridization in the wild type (A-F) and by GFP luminescence in the
heterozygotes (G-I) viewed laterally (A) and in transverse sections (B-I). (A)
At E8.5, Six1 is weakly expressed in the otic placode (arrowhead) and
the surrounding surface ectoderm. (B) At E9.5, Six1 is expressed in
the invaginating otic pit and (C) in the whole region of the otic vesicle
except the dorsalmost region. (D,G) At E10.5, Six1 is expressed in
the ventral half of the otic vesicle. (E) At E11.5 and (F,H) E12.5,
Six1 is expressed exclusively in the cochlea. (I) Expression of
Six1 in the cochlea is maintained at E14.5 embryos. (J) A bright
field image of the section in (I) stained with hematoxylin and eosin. More
than three embryos at each stage were analyzed and virtually the same results
obtained. d, dorsal; la, lateral. Scale bars: 100 µm.
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