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Fig. 3. sens is a repressor of the Egfr pathway. (A-D) Light micrographs of adult Drosophila eyes. (A) Egfr^Elp homozygotes have few ommatidia as well as prominent gaps of tissue between ommatidia (arrow). (B) sens mutant clone (unpigmented). The sens homozygous mutant tissue is roughened in appearance compared to sens heterozygous tissue, which is wild type in appearance (pigmented). (C) sens mutant clone (unpigmented) induced in an Egfr^Elp heterozygous background. Overall the eye is smaller, suggesting a dominant interaction between sens and Egfr^Elp. In the sens homozygous mutant area, there are reduced numbers of ommatidia, as well as gaps of tissue between ommatidia, similar to Egfr^Elp homozygotes (arrow, compare with A). (D) Expression of UAS-sens with ey-GAL4 in an Egfr^Elp homozygote is sufficient to suppress the Egfr^Elp phenotype. These results suggest that sens acts as a repressor of the Egfr pathway. (E,F) Third instar expression of an enhancer trap in the nuclear effector of the Egfr pathway, pnt¹²⁷⁷ (pnt-lacZ, red). pnt-lacZ is not expressed in Sens-expressing R8 cells (green, arrow), suggesting that the Egfr pathway is not activated to a high degree in the nucleus of R8.

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