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Fig. 2. Developmental changes of ventricular activation sequence and the expression
of Cx40 and ECE1. (A-C) Isochronal maps of action potential propagation
recording on the dorsal ventricular surface of looping, and septating stage
hearts. The first activation site is indicated in red. Developmental stages
and time resolution of each frame are also indicated. (D) Topological shift of
ventricular activation sequences from the immature to the mature pattern
during embryogenesis is presented as % of hearts exhibiting the apex-to-base
pattern. More than 12 hearts examined at each time point. (E-G) Whole-mount in
situ hybridization for Cx40 mRNAs (positive signals indicated by white arrows)
in hearts cut to half frontally at stages indicated. Insets are controls
stained with sense probes. (H) A transverse section of E8.5 heart stained for
Cx40. (I) High power view of the boxed area in H. (J-L) As in E-G but for ECE1
mRNAs. (M) As in H but for ECE1. (N) High power view of the boxed area in M.
at, atrium; avj, atrioventricular junction; ec, endocardium; ivs,
interventricular septum; lv, left ventricle; ot, outflow tract; rv, right
ventricle; tb, trabeculum.
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