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First published online February 2, 2004

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Cue motoneurone development

In the vertebrate nervous system, specialised cell types develop at characteristic positions. To investigate how the fine patterning of motoneurone subtypes is specified, Lewis and Eisen turned to zebrafish embryos in which three subtypes of primary motoneurones (PMNs) occur in a segmentally reiterated pattern along the spinal cord (see p. 891). Two of these PMN subtypes - middle primary (MiP) and caudal primary (CaP) - can be identified molecularly and by their axonal trajectories, i.e. by which tissue they innervate. Lewis and Eisen report that in zebrafish mutants that lack the overlying paraxial mesoderm, PMNs adopt a gene expression profile that has characteristics of both MiPs and CaPs. Furthermore, in mutants with severely disrupted paraxial mesoderm, although the PMNs have a hybrid gene expression profile, their axonal trajectories resemble those of CaP motoneurones. These results are consistent with the hypothesis that signals from the paraxial mesoderm specify the segmental pattern of PMN subtype identity in zebrafish.

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Related articles in Development:

Paraxial mesoderm specifies zebrafish primary motoneuron subtype identity

Katharine E. Lewis and Judith S. Eisen
Development 2004 131: 891-902. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?