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First published online February 2, 2004

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May the force be with you

Forces generated within microfilament rings are important during cellularisation of the early Drosophila embryo, according to Thomas and Wieschaus (see p. 863). During cellularisation, the embryonic membrane invaginates to surround the syncytial nuclei of the embryo. The cellularisation front - the leading edge of the invagination - is rich in cytoskeletal proteins, which suggests that contractile forces may be involved in invagination. Thomas and Wieschaus report that src64 and tec29, which encode tyrosine protein kinases involved in cytoskeletal regulation, are essential for the contraction of the microfilament rings present at the cellularisation front of the Drosophila embryo. They also show that Bottleneck, a protein previously shown to regulate cellularisation, counters the src64-dependent contraction of the microfilament rings. The researchers use these and other results to model how src64-dependent and src64-independent forces may be involved in cellularisation.

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Related articles in Development:

src64 and tec29 are required for microfilament contraction during Drosophila cellularization

Jeffrey H. Thomas and Eric Wieschaus
Development 2004 131: 863-871. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?