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Fig. 2. The wing is patterned by two morphogens, Hh and Decapentaplegic (Dpp). (A)
Hh produced in the posterior (P) compartment generates a short range gradient
of Hh in the anterior (A) compartment. Hh both patterns the central domain of
the wing and induces the expression of en, ptc and dpp, at
high, middle and low thresholds, respectively, in a stripe of cells adjacent
to the AP compartment boundary. Note that en is induced by Hh in the
anterior compartment in late larval development. Dpp induces expression of
sal and omb at high and low thresholds, respectively, and
patterns the wing beyond the central domain. (B) Ectopic expression of
hh results in a mirror image duplication of the entire A compartment
while Dpp induces a mirror image duplication of the A compartment lacking the
central domain (Zecca et al.,
1995). Reproduced with permission from Tabata
(Tabata, 2001).
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