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Fig. 4. Dpp signals through the Tkv receptor and directly activates target genes.
(A) Signaling pathway of Dpp. Dpp is received by a complex of type I (Tkv or
Sax) and type II (Put) serine/threonine kinase receptors. Binding of Dpp to
this receptor complex results in the activation of the receptor complex. The
activated Tkv directly phosphorylates Mad, which, upon phosphorylation,
translocates into the nucleus along with Medea (Med) and regulates
transcription of target genes, such as sal and omb.
(B-C') Activated Tkv directly upregulates sal expression. (B)
Sal in the wild-type wing disc (purple). (C,C') A clone of cells (marked
by an arrowhead in C and shown in green in the merged image C')
expressing an active form of Tkv (Tkv*) cause an upregulation of
sal expression in a region of the imaginal disc that does not
normally express sal, seen here alongside the region of imaginal disc
that normally expresses sal. Note the autonomy of the upregulation of
sal expression by Tkv (C').
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