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Fig. 9. The mode of action of Mili/Alk-mediated Jeb signalling during the determination and differentiation within the visceral and somatic mesoderm. At stage 10 (S 10) ventromedial somatic precursor cells start to express jelly belly (jeb, red cells) and secrete Jeb protein (small red dots) (Weiss et al., 2001). Some of these cells (red with green crescents) also express mili^Alk (green) and all visceral precursor cells express mili^Alk and bagpipe (bap) at this time. We conclude that Jeb signalling, especially the RTK pathway activation in visceral founder cells, depends on the level of Jeb protein reaching these cells. This activation leads in stage 11 (S 11) in the visceral mesoderm (vm) to the expression of dumbfounded/kin of irre (duf/kirre, blue) in the visceral founder cells (f), whereas the fusion-competent myoblasts (fcms) without an active pathway are characterised by sticks and stones (sns) expression. We further suggest that initial jeb expression in the somatic mesoderm (sm) is maintained mainly in lame duck/myoblast incompetent/gleeful (lmd/minc/glee)-expressing fcms responding on RTK pathway activation with differentiation into sns-expressing fcms. Nothing is known so far about the role of Jeb and Mili/Alk signalling in the ectoderm (ecto) and fat body (fb).

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