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Fig. 6. Follicle cell DNA endoreplication, but not gene amplification, is perturbed
by mutations in dm. (A) An overlay of DAPI/hGFP images shows a clone
of homozygous dm2/dm2 mutant cells
outlined in white. (B) An overlay of hGFP/anti-BrdU images of the same field
of follicle cells shows that a much smaller proportion of
dm2 mutant follicle cells than wild-type cells incorporate
BrdU. (C) An overlay of DAPI/hGFP images shows a large clone of
dm2/dm2 mutant cells, present in a
stage 11 egg chamber, outlined in white. (D) In the overlay of DAPI/BrdU
images of the same mutant clone, gene amplification can be detected by the
presence of puncta of BrdU incorporation in both the heterozygous and
dm2 mutant cells.
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