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Fig. 5. Hex control of ventral foregut morphogenesis and patterning. (A,B) In wild-type embryos, Hex (expressed in the blue domain) maintains the proliferation rate of the leading edge of ventral definitive endoderm cells during gut closure, resulting in the normal positioning of cells beyond the cardiogenic mesoderm and allowing the execution of the ventral pancreatic fate. (C,D) Owing to a defect in the proliferative rate of ventral definitive endoderm cells in Hex-/- embryos, the cells do not become positioned beyond the hepatogenic influence of the cardiac mesoderm and into the normal position of pancreatic induction, and the pancreas is not specified. Liver cells are still induced, but they continue to be less proliferative. s.t.m., septum transversum mesenchyme.





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