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Fig. 5. Tead2 activates transcription of a reporter construct containing NCE2. Co-transfection of a reporter construct containing NCE2 with Tead2 results in minimal activation (bar 2) over baseline transfection with pcDNA3 (bar 1). Addition of the Tead co-activator YAP65 (bar 3) results in a 3.5-fold activation over baseline. Mutation of the Tead binding site in NCE2 (bar 4) abolishes activation. YAP65 alone (bar 5) is unable to activate luciferase expression. Results are normalized for transfection efficiency and expressed as the mean ± standard deviation of three experiments, each performed in triplicate.





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