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Fig. 2. src64 is required for microfilament ring contraction during
cellularization. Cross-sections (A,B,E,F) and projections of confocal sections
of the cellularization front (C,D,G,H) of wild-type (A,C,E,G) and
src64
17 mutant (B,D,F,H) embryos, before
(A-D) and after (E-H) the cellularization front has passed the bases of the
nuclei. Embryos were stained with antibodies to myosin (A-H) and Armadillo
(E,F). The early cellularization front, shown by myosin localization, is of
uniform depth along the circumference of wild-type embryos (A), but is of
non-uniform depth in src64 mutant embryos (B). The newly formed
microfilament rings are round during early cellularization in wild-type
embryos (C), but are less rounded in src64 mutant embryos (D). The
late cellularization front is of uniform depth along the circumference of
wild-type embryos (E) and the furrow canals are expanded into a flask-like
shape, whereas in src64 mutant embryos, the late cellularization
front is also of uniform depth but the furrow canals are unexpanded (F). The
microfilament rings of wild-type embryos during late cellularization are round
and constricted (G), whereas the microfilament rings of src64 mutant
embryos are less rounded and are not constricted (H), similar to the
microfilament rings of src64 mutant embryos during early
cellularization (D). Scale bar: 10 µm.
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