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Fig. 4. Effects of Wnt8 misexpression. (A-C) Three-somite stage embryos globally expressing wnt8 ORF1 showing expression of fgf8 (A), erm (B) and pax8 (C). The r4 domain of fgf8 is indicated. The weaker anterior fgf8 expression corresponds to midbrain-hindbrain boundary. Asterisks mark the anterior limit of the neural plate. (D) pax8 expression in an embryo globally expressing ORF1 and coinjected with fgf3-MO and fgf8-MO. Preotic expression is nearly ablated. (E) Ectopic otic vesicles (arrowheads) in a live embryo at 30 hpf globally expressing ORF1. Note that anterior sensory structures and morphological landmarks in the brain such as the midbrain-hindbrain boundary and epiphysis are not produced. (F) Loss of otic tissue in a 30 hpf embryo globally expressing ORF1 and coinjected with fgf3-MO and fgf8-MO. (A-D) Dorsal views with anterior upward. (E,F) Lateral views with anterior to the left. Scale bars: A-D, 200 µm; E-F, 75 µm.





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