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Fig. 2. Foxl2lacZ expression during organogenesis of the ovary. ß-galactosidase staining of 12.5 dpc gonads (A,B), newborn (C,D) and adult ovaries (E,F) from Foxl2lacZ heterozygous animals. (A,B) Foxl2lacZ expression is sexually dimorphic. No expression is detected in male gonads, whereas Foxl2lacZ expression starts at around 12.5 dpc in female gonads. (C,D) In newborns Foxl2lacZ expression is detected in the somatic cells of the ovary. (E,F) In adult ovaries Foxl2lacZ expression is seen in granulosa cells with the highest levels in early follicles (black arrowheads), whereas expression declines during later stages of folliculogenesis (white arrowheads).





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