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Fig. 10. FOXA2 inhibits Muc5ac transcription. H292 cells were transfected with promoter plasmid pGL3-MUC5AC-luc and increasing amounts of the expression plasmid pRC-CMV-FOXA2. MUC5AC promoter activity was determined by the relative luciferase activity normalized to ß-galactosidase activity. As a positive control, all trans-retinoic acid (3 µgml-1) was added to induce MUC5AC expression. Plasmid pRC-CMV was used as empty vector control. *P<0.05 versus control (ANOVA).





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