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Fig. 11. FOXA2 staining of human lung tissue with goblet cell hyperplasia. (A)
Photomicrograph (x40) of a small conducting airway of a 5-month-old
infant who died with bronchopulmonary dysplasia. The nuclei of Alcian
Blue-stained mucus cells are unstained by the FOXA2 antibody. A few cells with
FOXA2-stained nuclei are observed in the basal layer of the conducting airways
and a nearby terminal airway. (B) Photomicrograph (x10) of the lung from
the patient in A, showing a cuboidal lined alveolar duct arising from the
small columnar cell lined bronchus. The nuclei of the Alcian Blue-stained
mucus cells in the bronchus lack FOXA2, but most of the nuclei of the cells
lining the alveolar ducts are FOXA2 reactive. (C) Photomicrograph (x40)
of the lung of a 27-year-old female who underwent lobectomy for
bronchiectasis. This shows a small bronchus lined with Alcian Blue-stained
mucus cells, the nuclei of which lack FOXA2 staining. Many nuclei of
non-goblet cells lining terminal airways are FOXA2 reactive. (D).
Photomicrograph (x10) of the lung of a 6.5-month-old infant dying with
bronchopulmonary dysplasia showing terminal airway cell nuclei immunostained
for FOXA2. Nuclei of epithelial cells lining a small conducting airway lack
Alcian Blue staining and are immunostained by the FOXA2 antibody. Scale bar:
50 µm.
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