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Fig. 4. Goblet cell hyperplasia after Foxa2 deletion. (A-H) Compound transgenic mice, either SP-C-rtTA^-/tg, (tetO)₇CMV-Cre^-/tg, Foxa2^loxP/loxP (C,E,G) or CCSP-rtTA^-/tg, (tetO)₇CMV-Cre^-/tg, Foxa2^loxP/loxP (D,F,H), and controls (non-Foxa2 deleted) (A,B) were treated with doxycycline from E0. At PN16, lung sections were stained for FOXA2 (arrows) and either Alcian Blue or periodic acid Schiff (PAS). Staining by Alcian Blue was observed in cells with goblet cell morphology (A-D, arrowheads). Similarly, PAS (E,F, arrowheads) and MUC5AC staining (G,H, arrowheads) were observed in goblet cells in conducting airways in Foxa2-deleted mice. FOXA2 staining was absent in nuclei of the goblet cells (C-H). Figures are representative of at least four individual mice of each genotype. Scale bar: 200 µm.

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