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Fig. 9. Effects of IL4 on FOXA2 are STAT6 dependent. (A-H) Adult, control (A-D) and Stat6-/- (E-H) mice were treated intranasally with IL4. Lung sections were prepared and stained for FOXA2. The mice were treated with either saline (A,B,E,F) or IL4 (C,D,G,H). IL4 induced goblet cell hyperplasia in control but not Stat6-/- mice. Foxa2 staining decreased at sites of goblet cell hyperplasia in wild-type mice. Foxa2 staining and epithelial cell morphology were not perturbed in Stat6-/- mice. Figures are representative of four mice of each genotype. Scale bars: 50 µm.





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