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Fig. 3. Loss-of-function clones of tws^P affect wing margin. (A,B) Cuticle of phenotypes displayed by the mitotic clones of tws^P. We observed characteristic serrated-margin phenotypes in both anterior (A) and posterior (B) compartments. (C,D) Wing discs with tws^P/tws^P clones. tws⁺/tws⁺ cells are marked with GFP. Note large clusters of tws⁺/tws⁺ cells with smaller or no associated tws^P/tws^P spots (C). Occasionally larger clusters of tws^P/tws^P cells were also seen (D). (E-H) Wing discs with tws^P/tws^P clones stained for Wg (E), Ct (F), Dll (G) and vg-QE (H). Arm-lacZ (red) was used to mark tws^P/tws^P clones in E-G, and GFP was used in H. For all the discs, the viability of tws^P/tws^P clones were confirmed by DAPI staining (data not shown). We did not observe any change in Wg expression levels, while Ct showed marginal reduction in its levels. Partial to complete loss of Dll and vg-QE was observed in tws^P/tws^P clones.

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