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Fig. 7. Msx3 and late activation of Bmp signaling induce dorsal interneuron cell fates at the expense of ventral cell fates. (A-D) Lhx2/9 (red) and Lhx1/5 (green) immunofluorescence labeling shows a ventral expansion of Lhx2/9⁺ dI1 population in embryos overexpressing Msx3 (A,B), ca-Bmpr1a/b (D) but not Msx3a (C). (E-H) Isl1 (red) and Pax2 (green) labeling shows a ventral expansion of Isl1⁺ dI3 population in embryos electroporated with Msx3 (E,F), ca-Bmpr1a/b (H) but not Msx3a (G). (I-L) Mnr2 (red) and Pax2 (green) labeling shows no significant dorsal expansion of Mnr2⁺ motoneurons. dI1-6, dorsal interneuron populations 1-6; MN, motoneuron; V0-1, ventral interneuron populations 0 and 1. Brackets outline the size of each neuronal population indicated. Arrowheads in A,E,I indicate the dorsal midline. In all panels, left is the control side and right is the electroporated side. Scale bars: 150 µm in A,E,I; 75 µm in B-D,F-H,J-L.

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