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Fig. 5. Binding to and inhibition of Bmp4 signaling by HtrA1 mutants. Schematic
presentation of each HtrA1 mutant is shown on the left. Numbers indicate the
amino acid residues. The table on the right summarizes the activities of HtrA1
mutants to bind and inhibit Bmp4. The binding activity was designated as `+'
when higher than 3% but less than 10% of input HtrA1 mutant protein was
recovered by the GST pull-down assay, and `-' when the recovery was less than
1%. Inhibitory activity of the wild-type HtrA1 was defined as 100% for each
amount of vector DNA (50 or 100 ng) added to the well. SS, signal
sequence.
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