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Fig. 4. Targeted expression of Tsh genes in the fly eye cause the same defects as
misexpressed tsh. (A,C) Ectopic eye development in
dpp>tsh (A) and dpp>Tsh3 (C) ventral to the normal eye
in the pharate adult raised at 25°C (arrows). About half
dpp>Tsh1 (not shown), dpp>Tsh3 flies (n=36
and n=41 respectively) and one third of dpp>Tsh2 flies
(n=57, not shown) show ectopic eye development. (B,D) Scanning
electron micrographs of the heads of ey>tsh (B) and
ey>Tsh2 (D) flies raised at 25°C showing impaired eye
development. A wild-type eye is shown in the inset in B. About one third of
ey>Tsh1 (n=45, not shown) and ey>Tsh3
(n=29, not shown), and 15% of ey>Tsh2 (n=63)
flies do not develop eyes. tsh expression leads to eye defects in
more than 80% of the flies (dpp>tsh, n=28 and ey>tsh,
n=33).
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