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Fig. 4. Merkel cells are increased in K14-noggin and decreased in K14-BMP4 mice.
Innervation to the mouth of whisker follicles in wild-type, K14-noggin and
K14-BMP4 mice as shown by double-label immunofluorescence with anti-NF200
(Cy3) and anti-PGP (Cy2). e, epidermis at the mouth of a whisker follicle. A-D
are from an Fvb background; E,F are from CB6F1 background. The broken line
indicates the border between the epidermis and dermis. Green arrowheads
indicate examples of FNEs in the epidermis which are labeled only with
anti-PGP. Note that the epidermis of the K14-noggin mice contains far more
FNEs and that the K14-BMP4 mice have fewer FNEs than their corresponding
wild-type littermates. Yellow curved arrows indicate Merkel endings labeled
with anti-NF200 and anti-PGP that terminate on Merkel cells (asterisks)
labeled only with anti-PGP. Note that the Merkel cells and innervation are
increased in K14-Nog and decreased in K14-BMP4 mice.
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