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Fig. 4. Notch-mediated asymmetric cell divisions are influenced by localized
determinants. (A) An asymmetric cell division in which one cell divides to
give two daughters that adopt different fates; Notch signaling is `on' in the
green cell and `off' in the red cell. Although both cells express Notch and
Delta, signaling is directional because the red cell inherits determinants
[such as Numb (red crescent in the mother cell)] that inhibit Notch signaling
in that cell. (B) Crescents are centered on one end of the mitotic spindle and
segregated into only one daughter cell. Here, a crescent of Partner of
Numb-GFP is visualized along with the spindle, which is labeled with tau-GFP
(image courtesy of Fabrice Roegiers). (C) The two exterior cells of a
Drosophila mechanosensory bristle are produced by the lineage shown
in A. The shaft cell (sh) activates Notch signaling in its sister, the socket
cell (so); the shaft cell does not have activated Notch because it inherits
Numb. Activation of Notch in both cells results in two sockets (D), whereas a
failure to activate Notch in either cell results in two shafts (E) (images
courtesy of Scott Barolo).
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