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Fig. 4. The sonic hedgehog pathway is disrupted in Brn3b-/- retinas. (A) Real-time RT-PCR analysis of genes belonging to the sonic hedgehog pathway. Red is for wild-type and green is for Brn3b-/-. ß-actin was used as RNA input control. Three genes, sonic hedgehog (Shh), Gli1 and patched 2 (Ptch2), were significantly downregulated in Brn3b-/- retina, while other genes showed no change. (B) In situ hybridization of Shh, Gli1 and Smo on E14.5 Brn3b heterozygous (+/-) and null (-/-) sections. Gli1 and Smo were expressed in progenitor cells and Shh in RGCs. Gli1 and Shh were downregulated in Brn3b-/- retinas, while Smo showed no change.





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