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Fig. 5. Effect of the expression of TAp73 or {Delta}Np73 transgenes on OPC differentiation. Purified P7 rat OPCs were cultured and analysed as in Fig. 3, except that they were infected with either pBird, pBird-TAp73 or pBird-{Delta}Np73 vectors. The differences between the pBird and the pBird-TAp73 results in PDGF, PDGF+TH and PDGF+RA are statistically significant when analysed by Student's t-test (p=0.03, 0.03 and 0.02, respectively). The differences between the pBird and the pBird-{Delta}Np73 results in PDGF, PDGF+TH, PDGF+RA and without PDGF are also statistically significant (p=0.04, 0.004, 0.03 and 0.001, respectively).





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