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Fig. 6. Effect of {Delta}Np73 transgene on the differentiation of wild-type and p53-/- OPCs. Cells were dissociated from P7 mouse optic nerve and cultured in PDL-coated Nunc slide flasks for 3 days in PDGF alone. They were then infected for 3 hours with either the pBird control vector or the pBird-{Delta}Np73 vector. After a further day in PDGF alone, they were then either kept in PDGF alone (A) or switched to either PDGF and TH (B) or medium without PDGF (C). After various times, they were fixed and stained for GC. The differences between the pBird and the pBird-{Delta}Np73 results in all cases are statistically significant when analysed by Student's t-test (in A, p=0.02 for p53+/+ and 0.05 for p53-/-; in B, p=0.002 for p53+/+ and 0.01 for p53-/-; in C, p=0.03 for p53+/+ and p=0.02 for p53-/-).





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