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Fig. 4. Homeotic transformations in the cervical vertebral column. Isolated individual vertebrae and cervical vertebral columns after Alcian blue/alizarin red staining. Ventral processes (anterior tuberculi) present at wild-type vertebrae C6 (A,A') were unilaterally or bilaterally missing (black arrowheads) in hemizygous (B,B'') and homozygous (C,C') msd::Dll1^dn and most double heterozygous msd::Dll1^dn; Dll1^lacZ/+ (D,D') mice. In hemi- or homozygous animals this was accompanied by the presence of ventral structures (white arrowheads, B,B',C,C') and/or transverse foraminae (arrows, B,C) on C7 and reduction of ribs at T1 (grey arrowheads, C). In msd::Dll1^dn; Dll1^lacZ^/+ mice aberrant ventral processes were found on C5 or C7 (white arrowheads, D,D'). In some heterozygous Dll1^lacZ mutant mice rudimentary ribs were attached to C7 (asterisks, E,E'). Arrows in (A) point to the foramina at C3-C6.

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