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Fig. 1. Analysis of the middle ear ossicles in E18.5 Bapx1-/-
mice. Alizarin Red and Alcian Blue staining of dissected middle ears from
E18.5 wild-type (A) and Bapx1-/- (B) embryos. Development
of the middle ear bones appears to be largely unaffected by loss of
Bapx1 expression. The stapes and incus develop normally, as do the
joints between the three middle ear ossicles (inserts in A and B, and data not
shown). Although elements of the malleus, such as the processus brevis and the
manubrium appear normal, the body of this ossicle is significantly narrower in
mice lacking Bapx1 (B,C). The length of the malleus is unaffected in
Bapx1-/- mice (B,D). Measurements of malleal width and
length were taken between the T-bars indicated in A. I, incus; M, malleus; MM,
manubrium of the malleus; PB, processus brevis.
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