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Fig. 3. Distinct combination of Hox genes is required for Mash1-dependent Phox2b protein expression in r4 and r5. Transverse sections through r4 and r5 of E10.5 control (A,E), Hoxb1^-/- (B,F), Hoxa3^-/-b3^-/- double (C,G) and Mash1^-/- (D,H) embryos. The expression of Phox2b among precursors of noradrenergic visceral interneurons is missing (compare with arrows in A,C,E,F) in dorsal r4 of Hoxb1^-/- and dorsal r5 of Hoxa3^-/-b3^-/- embryos compared with controls. In the Mash1^-/- embryo, Phox2b expression is completely eliminated in the dorsal region of r4 and r5. VII/VIIIg, ganglia; OV, otic vesicle.

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