|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 4. Loss of precursors of noradrenergic visceral sensory interneurons is
associated with the expansion of neighboring interneurons in r5 and r4.
Transverse sections through r5 and r4 of E11.5 control (A,C),
Hoxa3-/-b3-/- (B) and
Hoxb1-/- (D) embryos. The co-expression (yellow) of Phox2b
(green) and Lmx1b (red) among noradrenergic precursors is eliminated in the
dorsal hindbrain of Hoxa3-/-b3-/- and
Hoxb1-/- embryos. The intermediate column of Phox2b and
the more ventral population of Lmx1b-expressing cells appear unaffected in the
Hox mutant embryos. The domain of Lim1/2 (blue, bracket) expression has
expanded in both Hox mutant embryos compared with controls. Comparison of
transverse sections at comparable DV axial levels through r3 of an E11.5
control embryo (E-G) with r5 and r4
Hoxa3-/-b3-/- and
Hoxb1-/- mutant embryos (B,D) show similar expression patterns
of Phox2b, Lmx1b and Lim1/2.
|
