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Fig. 5. Regulation of proprioceptive and somatic sensory interneurons is independent of Hoxb1, Hoxa3 and Hoxb3 functions in r4 and r5. Expression of LH2A/B (green, arrow) and Lim1/2 (red) in r4 and r5 of controls (A,C) compared with Hoxb1-/- (B) and Hoxa3-/-b3-/- (D) embryos. Lim1/2 expression is expanded in both Hox mutant embryos compared with their controls. Expression of Lbx1 (green) and Lim1/2 (red) in E11 control (E) and Hoxb1-/- (F) embryos and E11.5 control (G) and Hoxa3-/-b3-/- (H) embryos is intact. The co-expression of Lim1/2 and Lbx1 suggests that the Lbx1 population is also expanded in Hox mutant embryos compared with controls (bracket).





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