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Fig. 7. Summary. (A) Schematic view of a flat-mount hindbrain showing Hox gene
expression on the left (bars) and first-order visceral (noradrenergic),
somatic and proprioceptive sensory relay interneurons (circles) on the right.
The loss of Hoxb1 (B) and the combination of Hoxa3 and
Hoxb3 (C) result in a specific loss of visceral interneurons in r4
and r5, respectively. The loss of visceral sensory interneurons in these Hox
mutant embryos is associated with the expansion of the somatic sensory
interneuron domain. In Hoxa2 loss-of-function (D), somatic sensory
interneurons are completely eliminated in r2 and significantly reduced in r3,
presumably through the redundant role of Hoxb2 in this rhombomere
(see A). Although Hox genes are expressed throughout the early
neuroepithelium, the present finding suggests a specific role for Hox genes in
the generation of cellular diversity in the developing hindbrain.
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