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Fig. 8. Wnt/ß-catenin signaling is required for mitfa expression and branchial arch expression of dlx2 upon crest migration. (A,B) Whole-mount in-situ hybridization for melanophore-specific marker, mitfa. (C,D) Whole-mount in-situ hybridization for neural crest marker, sox10. (E-H) Whole-mount in-situ hybridization for cranial neural crest marker, dlx2. Black arrowhead indicates few remaining mitfa-expressing cells. Open arrowhead indicates normal pattern of sox10-expressing neural crest. While telencephalon and diencephalon expression is unchanged in {Delta}TCF transgenic embryos, dlx2 expression is observed in the developing branchial arches. All images are lateral views, anterior to the left, of wild-type siblings (A,C,E,G) and hs{Delta}Tcf-GFP transgenic embryos (D,E,F,H) after heat shock at the 18-somite stage and fixation at the 26-somite stage, except (G,H) which are dorsal views of flat-mounted embryos, anterior to the left.





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