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Fig. 6. Modeling of Class II bHLH structures place subclass-specific amino acids
residues on an external surface of the dimer. (A) Alignment of amino acid
residues from the bHLH domain of neural bHLH factors and MyoD. A
representative from mouse for each neural sub-class is shown; Mash1, the
Achaete-scute family; Math1, the Atonal family; Ngn1, the Neurogenin family;
Nscl1, the Nscl family; NeuroD, the NeuroD family. Residues in red highlight
the residues conserved between all Class II bHLH factors. Residues in blue are
conserved within members of a specific sub-family but are unique between the
sub-families. (B) Mash1 bHLH monomer modeled onto the crystal structure of
MyoD. The interfaces between the E-protein heterodimer partner and DNA are
shown. Note the residues conserved between all Class II bHLH factors provide
these interfaces (red). The residues unique to each sub-family (blue) provide
surfaces for additional interactions.
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