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Fig. 6. BC sublaminar targeting errors follow AC errors in lak mutants. Confocal images of cross sections of line 220 wild-type (wt) and lak mutant retinas (6 dpf), immunolabeled for protein kinase C (PKC). Staining is seen in BCs with axon terminals stratifying in three sublayers of the on (i.e. proximal) region of the IPL. In wild type, only one of the two major GFP+ AC sublaminae overlaps with the PKC-immunoreactive terminals, indicating that one is within the ON sublayer and the other is within the OFF sublayer. In lak, the orderly arrangement of the BC terminals is disrupted only in regions where the GFP+ AC sublaminae are perturbed. Arrows indicate a local region within which the OFF GFP+ lamina appears relatively normal (if contorted), and the ON lamina is either missing or displaced to the outer IPL. In this region, ON BC terminals (red arrowheads) are excluded from the ON sublamina, although a few puncta have aligned with diffuse GFP+ processes in the OFF sublamina (green arrowheads).





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