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Fig. 3. Embryonic expression of tfap2a. (A,E,G,I,K) Lateral and
(B,D,F,H,J) dorsal views of embryos stained with a tfap2a riboprobe
(B,D-K, anterior is towards the left). (A) Expression at 50% epiboly is spread
throughout the blastoderm with a slightly stronger expression at the most
dorsal aspect of the embryo. (B,C) tfap2a expression in neural crest
progenitors at the two-somite stage. Arrowhead in B indicates the level where
the optical section was taken in C. (D,E) Cranial premigratory neural crest
cells express tfap2a at the 10-somite stage. (F,G) Expression extends
to migratory neural crest cells (arrowheads), intermediate mesoderm, brain and
spinal cord neurons. (H,I) tfap2a message is found in brain and
spinal cord neurons, neural crest streams in the head (arrowhead), in the
epidermis and the paired pronephric ducts. (J,K) At 24 hpf, the expression in
the brain is confined to the two anterior domains and the hindbrain
rhombomeres. At this time, increasing numbers of spinal cord neurons and the
migrating lateral line primordium (arrow) express tfap2a. Arrowheads
indicate the craniofacial primordia. (L) Dorsolateral view of the head at 36
hpf. The expression in the primordia of the epibranchial ganglia is visible as
a stripe of cells (arrowheads) between the otic vesicle and the pharyngeal
arches. e, eye; ep, epidermis; hb, hindbrain rhombomeres; im, intermediate
mesoderm; llp, lateral line primordium; nc, neural crest; np, neural plate;
ov, otic vesicle; pnd, pronephric ducts; sc, spinal cord neurons.
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