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Fig. 5. Neural derivatives of neural crest require tfap2a activity. (A,C,E,F,I,K) Wild-type and (B,D,G,H,J,L) mob^m610 embryos. (A,B) foxd3 expression in cranial ganglia-associated glia at 24 hpf. The red arrow indicates the preotic ganglia and the blue arrow the postotic ones. (C,D) neurod expression in cranial ganglia precursors at 24 hpf. (E-H) Anti-Hu antibody staining of cranial ganglia at 4 dpf. In E and G, the arrow (tg) points to the most anterior cluster of trigeminal/facial/anterior lateral line ganglia that are greatly reduced in the mutants (G). The images in F and H focus on the posterior ganglia and show loss of mll and ventral ganglia. (I,J) Anti-Hu staining in the trunk of 4 dpf embryos shows scattered DRGs (arrows) and absence of enteric neurons in the distal part of the digestive tube in mob^m610 embryos (DRGs from the other side of the embryo also show-through in wild-type and mutant embryos). (K,L) The expression of the dopamine beta hydroxylase (dbh) gene in sympathetic neurons (sn) is completely missing in mob^m610 mutant embryos at 48 hpf (arrowhead in L). all, anterior lateral line ganglia; DRG, dorsal root ganglia; en, enteric neurons; LC, locus coeruleus; mll, medial lateral line ganglia; o, octaval/statoacustic ganglia; ov, otic vesicle; pll, posteriolateral line ganglia; sn, sympathetic neurons; tg, trigeminal ganglia; IX, glossopharyngeal nerve ganglia; X, vagal nerve ganglia.

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