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Fig. 7. mobm610 mutant embryos fail to express pre-chondrogenic genes in cranial neural crest streams populating the pharyngeal arches. (A,C,E,G) Wild-type and (B,D,F,H) mobm610 mutant embryos at 24 hpf. (A-D) In situ hybridization analysis of dlx2 (A,B) and hoxb2a expression (C,D). Note normal expression of hoxb2a in hindbrain rhombomeres 3 to 5. (E-H) In situ hybridization analysis of sox9a (E,F) and wnt5a (G,H). The red arrowheads indicate the second neural crest stream and the black ones the first and postotic streams. All panels show dorsal views of flat-mount preparations, anterior towards the left. e, eye; ov, otic vesicle.





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