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Fig. 8. Fate mapping of cranial neural crest. (A,C) Confocal microscope images of
8-somite stage embryos depict the region of UV-laser uncaged fluorescein
dextran in the dorsal hindbrain. The arrowheads point to the first somite.
(B,D) Confocal microscope images of the same animals as shown in A and C at 24
hpf reveal the fate of migratory neural crest in wild-type (B) and
mobm610 mutant (D) embryos. In the mutant embryo, the
third stream of migratory neural crest fails to subdivide and populate the
most posterior pharyngeal arches. Arrows indicate the normal migrating streams
towards the pharyngeal arches in wild-type embryo (B) and to the masses of
premigratory cells stuck at the position of the preotic and postotic streams
in mobm610 mutant (D). Lateral views. ov, otic vesicle; e,
eye; mhb, midbrain-hindbrain boundary.
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